T Cell Activation

B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation

Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...

Modelling T Cell Activation

The recognition of foreign antigen by T cells is the foundation of the adaptive immune response, and this has been demonstrated experimentally to be an extremely sensitive, specific and reliable process. In this thesis, models for T cell signalling based on recent experimental data are constructed to understand how these properties arise. The thesis first reviews the biological and mathematical...

T-Cell Activation: Two for T

T-cell activation requires costimulation in addition to the antigen-specific signal. Recent results suggest that distinct costimulatory molecules can specifically activate different types of T-cell response.

1452 Resting T Cell Activation

The structure of the putative T cell antigen receptor has been defined using monoclonal antibodies (mAb) 1 prepared against various monoclonal T cell populations in several laboratories (1-3), including our own (4, 5). These reagents have defined an 80-90 kilodalton (kD) disulfide-linked heterodimer usually composed of a 49-53 kD alpha chain of acidic pI and a 41-43 kD beta chain of more basic ...

Optimal T Cell Activation and B Cell